DNA-PK Inhibitor V-CAS 404009-46-7-Calbiochem

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一般描述

A morpholino-benzophenone compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of DNA-PK (IC₅₀= 270 nM). Inhibits PI 3-K catalytic subunit p110-isozymes at higher concentrations (IC₅₀= 32 ?M, 3.7 ?M, 22 ?M and ~ 100 ?M for α, β, δ and γ, respectively) and weakly inhibits a panel of several other kinases, including, ATM, ATR, CK2, GRK2, mTOR, PI 3KC2α, PI 3KC2β, PI 3KC2γ and PI 4Kβ, even at concentrations as high as 50 ?M.
A potent, selective, reversible, and ATP-competitive inhibitor of DNA-PK (IC₅₀= 0.27 ?M). Inhibits the PI 3-K catalytic subunit p110-isozymes at higher concentrations (IC₅₀= 32 ?M, 3.7 ?M, 22 ?M and ~100 ?M for α, β, δ and γ, respectively). Only weakly inhibits a panel of several other kinases, including, ATM, ATR, CK2, GRK2, mTOR, PI-3KC2α, PI-3KC2β, PI-3KC2γ and PI-4Kβ, even at concentrations as high as 50 ?M.

包装

1, 5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Target IC₅₀: 270 nM against DNA-PK
Primary Target
DNA-PK
Product competes with ATP.
Cell permeable: no
Reversible: yes

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Knight, Z.A., et al. 2004.Bioorg. Med. Chem.12,4749.
Willmore, E., et al. 2004.Blood,103,4659.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

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