半岛bd体育手机客户端 说明

一般描述

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.

应用

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) may be used in the following studies:

• As coupling reagent in the preparation strategies for peptide-oligonucleotide conjugates.
• Synthesis of structured pure triacylglycerol (TAG) regioisomers.
• As coupling reagent in the synthesis of a 3,5-pyrazolidinedione on soluble polyethylene glycol (PEG) polymer support.
• Synthesis of herceptin- nanoparticles.

BOP 偶联剂类似物，不产生致癌副产物 HMPA。

法律信息

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

线性分子式	C18H28N6OP · PF6
分子量	520.39
Beilstein	3584612
MDL编号	MFCD00077411
PubChem化学物质编号	329749882
NACRES	NA.22

半岛bd体育手机客户端 性质

质量水平	200
等级	purum
测定	≥97.0% (TLC)
reaction suitability	reaction type: Coupling Reactions
mp	~150 ℃ 154-156 ℃ (dec.) (lit.)
application(s)	peptide synthesis
储存温度	2-8℃
SMILES string	F[P-](F)(F)(F)(F)F.C1CCN(C1)[P+](On2nnc3ccccc23)(N4CCCC4)N5CCCC5
InChI	1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1
InChI key	VIAFLMPQBHAMLI-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H317 - H410
预防措施声明	P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352
危险分类	Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves