Bisindolylmaleimide II

半岛bd体育手机客户端 说明

应用

Bisindolylmaleimide II (BIS II) has been used:

• as a protein kinase C (PKC) inhibitor to study its effects on cardiomyocyte phenotypes
• as a PKC inhibitor along with methanandamide (mAEA) to study its effects on murine gastric vagal afferent (GVA) mechanosensitivity
• as a PKC/protein kinase A (PKA) inhibitor to study its effects on bone-marrow cells

生化/生理作用

Bisindolylmaleimide II (BIS II) acts as a dual protein kinase A/C (PKA/C) inhibitor.

基本信息

经验(实验)分子式	C27H26N4O2
分子量	438.52
MDL编号	MFCD00236430
PubChem化学物质编号	329773212

半岛bd体育手机客户端 性质

质量水平	200
生物来源	synthetic (organic)
测定	≥97% (Mixture of 2 isomers)
形式	powder
溶解性	DMSO: soluble ethanol: soluble
运输	dry ice
储存温度	?20℃
SMILES string	CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26
InChI	1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33)
InChI key	LBFDERUQORUFIN-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)