Sphingosine 1-phosphate ready made solution

半岛bd体育手机客户端 说明

一般描述

Sphingosine 1-phosphate (S1P) is a sphingolipid derived from ceramide by an enzymatic reactionin vivo.¹S1P acts as a signaling molecule by binding to G-protein coupled receptors (S1PR) (S1P1-5 receptors) which results in activation of small GTPases such as Ras, Rac Rho and further downstream intracellular effects such as PI-3-Kinase, Protein kinase C and Hippo signaling pathways. This generates an effect on cell migration, differentiation and survival and therefore effects variety of systems such as immune system, central nervous system and cardiovascular system.²For instance, S1P was found to inhibit cell apoptosis and induce cell proliferation by binding S1P1 to promote activation of ERK pathway.³In addition, S1P was found to support cancer cells by inducing angiogenesis and survival of proliferative cells in the tumor microenvironment.⁴Due to the vast activities of S1P and the resulted S1PR irregular activation, large discovery efforts are made to identify therapy by S1PR antagonists.⁵

生化/生理作用

Anti angigoenesis

其他说明

Sphingosine 1-phosphate ready made solution is supplied in aqueous solution at 10mM concentration and can be further diluted (X10000) to a working concentration of 1μM.

基本信息

半岛bd体育手机客户端 性质

安全信息