半岛bd体育手机客户端 说明
一般描述
Reagent-cartridge CRBN-PEG2is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC?(proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected aldehyde or ketone to the amine terminated linker through a reductive amination. This cartridge features a Cereblon (CRBN) recruiting ligand (pomalidomide) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation.
Scale:up to 0.1 mmol
Linker:PEG2
E3 ligase target and ligand:Cereblon (CRBN), pomalidomide
Terminal functional group:amine
Compatible substrates:ketone, aldehyde
Cartridge contents:
其他说明
An integrated console for capsule-based, automated organic synthesis
法律信息
Product of Synple Chem AG
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
半岛bd体育手机客户端 性质
质量水平 | 100 |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H315 - H319 |
预防措施声明 | P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313 |
危险分类 | Eye Irrit. 2 - Skin Irrit. 2 |
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich