PP1 Analog-CAS 221243-82-9-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC₅₀= 1.5 nM) compared to wild-type v-Src (IC₅₀= 1.0 ?M). Also inhibits wild-type Fyn (IC₅₀= 600 nM). Also available in InSolution format (Cat. No. 529605).
A potent, reversible, ATP-competitive, cell-permeable and selective inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC₅₀= 1.5 nM) compared to wild-type v-Src (IC₅₀= 1 ?M). Also inhibits wild-type Fyn (IC₅₀= 600 nM). Also available in InSolution format (Cat. No. 529605).

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Reversible: yes
Cell permeable: yes
Target IC₅₀: 1.5 nM against I338G mutant v-Src; 1.0 ?M against wild-type v-Src; 600 nM against wild-type Fyn
Primary Target
I338G mutant v-Src
Product competes with ATP.

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.

其他说明

Bishop, A.C., et al. 2000.Nature407,395.
Bishop, A.C., et al. 1999J. Am. Chem. Soc.121,627.

法律信息

Not available for sale in the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C19H19N5
分子量	317.39

半岛bd体育手机客户端 性质

测定	≥99% (HPLC)
质量水平	100
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze
颜色	off-white
溶解性	DMSO: 10 mg/mL
运输	ambient
储存温度	?20℃
InChI	1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22)
InChI key	XSHQBIXMLULFEV-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable