MMP-9/MMP-13 Inhibitor I-CAS 204140-01-2-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 (IC₅₀= 900 pM) and MMP-13 (IC₅₀= 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC₅₀= 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC₅₀= 930 nM).
A cell-permeable and highly, piperazine-based potent inhibitor of MMP-9 (IC₅₀= 900 pM) and MMP-13 (IC₅₀= 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC₅₀= 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC₅₀= 930 nM).

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
MMP-9
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 900 pM against both MMP-9 and MMP-13

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Cheng, M., et al. 2000.J. Med. Chem.43,369.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C25H25N3O6S
分子量	495.55

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	white
溶解性	methanol: 1 mg/mL DMSO: 100 mg/mL
运输	ambient
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable