半岛bd体育手机客户端 说明
一般描述
A component of membrane-bound receptors in association with phospholipase C. Hydrolysis of PIP2yields IP3and diacylglycerol, causing the release of intracellular Ca2+and activation of protein kinase C. Potently stimulates phospholipase D activityin vitroin brain tissue. A substrate for PI 3-kinase. Antagonist of ATP inhibtion of ATP-sensitive potassium (KATP) channels when applied to inside-out membrane patches.
Note:This product is not to be used for animal treatment,in vivoresearch or in any other contact procedure with livestock.
A component of membrane-bound receptors in association with phospholipase C (PLC). Potently stimulates brain phospholipase D (PLD) activityin vitro. Has been shown to activate protein kinase C (PKC) in the presence of phosphatidylserine and Ca2+. Antagonist of ATP-sensitive potassium (KATP) channels when applied to inside-out membrane patches.
包装
1 mg in Plastic ampoule
100 μg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Primary Target
Brain phospholipase D (PLD)
Product does not compete with ATP.
Reversible: no
Cell permeable: no
警告
Toxicity: Irritant (B)
重悬
Following reconstitution in H?O, store in the refrigerator (4°C). Do not freeze aqueous solutions. Following reconstitution in chloroform, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 days at 4°C. Chloroform stock solutions are stable for up to 1 month at -20°C.
其他说明
Baukrowitz, T., et al. 1998.Science282,1141.
Shyng, S.-L., and Nichols, C.G. 1998.Science282,1138.
Mazzotti, G., et al. 1995.J. Histochem. Cytochem.43,181.
Liscovitch, M., et al. 1994.J. Biol. Chem.269,21403.
Chauhan, A., et al. 1991.Biochem. Biophys. Res. Commun.175,852.
Williamson, J.R. 1986.Hypertension8,140.
Berridge, M.J., and Irvine, R.F. 1984.Nature312,315.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C47H82O19P3· 3NH4 |
| 分子量 | 1098.18 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (TLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 颜色 | white to off-white |
| 溶解性 | water: 10 mg/mL chloroform: 50 mg/mL |
| 运输 | wet ice |
| 储存温度 | ?70℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
