GSK-3β Inhibitor XII, TWS119-CAS 601514-19-6-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable and potent inhibitor of GSK-3β (IC₅₀= 30 nM). Binds to GSK-3β with high-affinity (K_d= 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 ?M) and embryonic stem cells (D3; 50-60% at 400 nM).
A cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3β (IC₅₀= 30 nM). Binds to GSK-3β with high-affinity (K_d= 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 ?M) and embryonic stem cells (D3; 50-60% at 400 nM).

包装

1, 5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Kd = 126 nM against GSK-3β
Product does not compete with ATP.
Reversible: no
Primary Target
GSK-3β

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Ding, S., et al. 2003.Proc. Natl. Acad. Sci. USA100,7632.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C18H14N4O2
分子量	318.33
MDL编号	MFCD09037535

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
效能	30 nM IC50
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	beige
溶解性	methanol: 2 mg/mL DMSO: 200 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3