Caspase-3 Inhibitor I-CAS 169332-60-9-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A very potent, specific, and reversible inhibitor of caspase-3 (IC₅₀= 200 pM), caspase-6, caspase-7, caspase-8, and caspase-10.
A specific and reversible inhibitor of CPP32/Apopain/Yama (IC₅₀= 0.2 nM). A member of the ICE/CED-3 family of cysteine proteases, which are important in apoptosis.

包装

1 mg in Glass bottle
5 mg in Plastic ampoule
Yes

生化/生理作用

Product does not compete with ATP.
Reversible: yes
Target IC₅₀: 200 pM against caspase-3
Cell permeable: no
Primary Target
Capase-3, capase-6, capase-7, capase-8, capase-10

警告

Toxicity: Standard Handling (A)

序列

Ac-Asp-Glu-Val-Asp-CHO

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Garcia-Calvo, M., et al. 1998.J. Biol. Chem.273,32608.
Thornberry, N.A., and Lazebnik, Y. 1998.Science281,1312.
Nicholson, D.W. 1996.Nature Biotech.14,297.
Schlegel, J., et al. 1996.J. Biol. Chem.271,1841.
Nicholson, D.W., et al. 1995.Nature376,37.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C20H30N4O11
分子量	502.47
MDL编号	MFCD00671412

半岛bd体育手机客户端 性质

质量水平	100
测定	≥90% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze
颜色	white
溶解性	DMSO: 5 mg/mL water: soluble
运输	ambient
储存温度	?20℃
InChI	1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)/t11-,12-,13-,17-/m0/s1
InChI key	UMBVAPCONCILTL-MRHIQRDNSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable