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位置: 首页> 品牌> Sigma-Aldrich> α-Amyloid Precursor Protein Modulator-CAS 497259-23-1-Calbiochem

α-Amyloid Precursor Protein Modulator-CAS 497259-23-1-Calbiochem

品牌
Sigma-Aldrich
CAS
497259-23-1
货号
565740
规格纯度
A cell-permeable benzolactam derived PKC activator (Ki= 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848.
价格
4349.22 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
497259-23-1
α-Amyloid Precursor Protein Modulator-CAS 497259-23-1-Calbiochem
(2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, PKC Activator V
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable benzolactam derived PKC activator (Ki= 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. Displays a marked loss of tumor promoting activity.
A cell-permeable PKC activator (Ki= 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) but lacks any tumor promoting activity.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target Ki: 11.9 nM for activating PKCα
Primary Target
PKC

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Kozikowski, A.P., et al. 2003.J. Med. Chem.46,364.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C27H30F3N3O3
分子量 501.54

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 orange
溶解性 methanol: 1 mg/mL
DMSO: 50 mg/mL
运输 wet ice
储存温度 ?20℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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