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位置: 首页> 品牌> Sigma-Aldrich> Triptolide,Tripterygium wilfordii-CAS 38748-32-2-Calbiochem

Triptolide,Tripterygium wilfordii-CAS 38748-32-2-Calbiochem

品牌
Sigma-Aldrich
CAS
38748-32-2
货号
645900
规格纯度
A novel diterpene triepoxide isolated from the Chinese herbTripterygium wilfordiithat acts as a potent immunosuppressant and anti-inflammatory agent.
价格
1410.99 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
38748-32-2
Triptolide, Tripterygium wilfordii-CAS 38748-32-2-Calbiochem
PG490
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A novel diterpene triepoxide isolated from the Chinese herbTripterygium wilfordiithat acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells, sensitizes tumor cells to TNF-α-induced activation of NF-κB. Also inhibits IL-2 expression in activated T-cells at the level of purine-box/nuclear factor and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1). Reported to induce apoptosis by activating DEVD-cleaving caspases.
A novel diterpene triepoxide isolated from the Chinese herbTripterygium wilfordiithat acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).

包装

1, 5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
Activate DEVD-cleaving caspases
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

其他说明

Zhao, Q., et al. 2005.J. Biol. Chem.280,8101.
Shepherd, E., et al. 2004.J. Biol. Chem.279,54023.
Chan, M.A., et al. 1999.Phytother. Res.13,464.
Lee, K.Y., et al. 1999.J. Biol. Chem.274,13451.
Qiu, D., et al. 1999.J. Biol. Chem.274,13443.
Yang, Y., et al. 1998.Immunopharmacology40,139.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C20H24O6
分子量 360.40
MDL编号 MFCD00210565

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 off-white
溶解性 DMSO: 20 mg/mL
运输 ambient
储存温度 ?20℃
InChI 1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
InChI key DFBIRQPKNDILPW-CIVMWXNOSA-N

安全信息

象形图 GHS06GHS08
警示用语: Danger
危险声明 H300 + H330 - H361f
预防措施声明 P201 - P202 - P260 - P264 - P270 - P304 + P340 + P310
危险分类 Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2
储存分类代码 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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