半岛bd体育手机客户端 说明
一般描述
A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD= 59 nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50= ～ 3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. A 10 mM (500 ?g/86 ?l) solution of Smoothened Agonist, SAG (Cat. No. 566661) in H2O is also available.
A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD= 59 nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50～3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.
A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD= 59 nM).
包装
1, 5 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Wang, J., et al. 2010.Proc. Natl. Acad. Sci. USA.107,9323.
Meloni, A.R., et al. 2006.Mol. Cell. Biol.26,7750.
Chen, W., et al. 2004.Science306,2257.
Chen, J.K., et al. 2002.Proc. Natl. Acad. Sci. USA99,14071.
Frank-Kamenetsky, M., et al. 2002.J. Biol.1,10.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C28H28ClN3OS · 2HCl · 2H2O |
| 分子量 | 599.01 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 颜色 | light yellow |
| 溶解性 | DMSO: 10 mg/mL water: 25 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
Sigma-Aldrich
m.cnreagent.com
