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位置: 首页> 品牌> Sigma-Aldrich> Phorbol-12,13-dibutyrate-CAS 37558-16-0-Calbiochem

Phorbol-12,13-dibutyrate-CAS 37558-16-0-Calbiochem

品牌
Sigma-Aldrich
CAS
37558-16-0
货号
524390
规格纯度
Strong irritant for mouse skin, but only moderately active as a tumor promoter.
价格
1296.97 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
37558-16-0
Phorbol-12,13-dibutyrate-CAS 37558-16-0-Calbiochem
PDBu, PKC Activator II
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Strong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C (PKC). Stimulates the phosphorylation of Na+-K+ATPase, thereby inhibiting its activity. Promotes the expression of iNOS in cultured hepatocytes. PDBu can be diluted to 30 ?M in aqueous solutions, so it is commonly used in binding studies or in applications requiring high concentrations. It is easier to remove PDBu than PMA from cells in culture.
Strong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C. Stimulates the phosphorylation of Na+,K+- ATPase, thereby inhibiting its activity. Promotes the expression of inducible NOS in cultured hepatocytes. Commonly used in binding studies or in applications requiring high concentrations of phorbol compounds.

包装

1, 5 mg in Alu drum
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Primary Target
Na+,K+- ATPase
Reversible: no
Cell permeable: no

警告

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

制备说明

Further dilute with aqueous buffers just prior to use.

重悬

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.

其他说明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Fisone, G., et al. 1995.J. Biol. Chem.270,2427.
Lee, E.J., et al. 1994.Brain Res.665,127.
Critz, S.D., et al. 1993.J. Neurochem.60,1175.
Iredale, P.A., et al. 1993.Biochem. Pharmacol.45,611.
Critz, S.D., and Byrne J.H. 1992.J. Neurophys.68,1079.
Hortelano, S., et al. 1992.J. Biol. Chem.267,24937.
Ward C.A., and Moffat, M.P. 1992.J. Mol. Cell. Cardiol.24,937.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C28H40O8
分子量 504.61
MDL编号 MFCD00036783

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥99% (HPLC)
形式 solid (crystalline)
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
颜色 clear
溶解性 DMSO: 10 mg/mL
运输 ambient
储存温度 ?20℃
InChI 1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1
InChI key BQJRUJTZSGYBEZ-YVQNUNKESA-N

安全信息

象形图 GHS05GHS06GHS08
警示用语: Danger
危险声明 H300 + H310 + H330 - H314 - H317 - H334 - H351
预防措施声明 P201 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
危险分类 Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
储存分类代码 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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