NF-κB SN50, Cell-Permeable Inhibitor Peptide-Calbiochem

半岛bd体育手机客户端名称：

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

NF-κB SN50, CAS 213546-43-3, is a cell-permeable peptide that contains the NLS sequence of NF-κB p50 linked to the hydrophobic region of K-FGF. Inhibits translocation of the NF-κB into the nucleus.
Contains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The peptide N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, inhibition of NF-κB nuclear translocation is maximally inhibited at 18 ?M.
Contains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 ?M.

包装

500 μg in Plastic ampoule
1 mg in Plastic ampoule

生化/生理作用

Product does not compete with ATP.
Cell permeable: yes
Primary Target
translocation of the NF-κB active complex into the nucleus

警告

Toxicity: Standard Handling (A)

序列

H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

其他说明

Lin, Y.-Z., et al. 1995.J. Biol. Chem.270,14255.

法律信息

Sold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₂₉H₂₃₀N₃₆O₂₉S
分子量	2781.50

半岛bd体育手机客户端性质

质量水平	100
测定	≥97% (HPLC)
形式	lyophilized
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze desiccated (hygroscopic)
溶解性	water: 5 mg/mL
运输	ambient
储存温度	?20℃