半岛bd体育手机客户端 说明

一般描述

A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange. Shown to cause a rapid activation of ERK1/2 (EC₅₀~ 2.5 - 5 ?M) in rat arterial smooth muscle and Rat2 cells. Also promotes the phosphorylation of JNK and p38 MAP kinase, phospholipase C and causes Ca²⁺release from internal stores. Negative control is also available (Cat. No. 371820).
A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange. Reported to cause a rapid activation of ERK1/2 (EC₅₀~2.5-5 ?M) in RASM (rat arterial smooth muscle) and Rat2 cells. Promotes the phosphorylation of JNK and p38 MAP kinase. Also increases phospholipase C activity and causes Ca²⁺release from internal stores.

包装

1, 5 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
N-myristoylated G-protein βγ selective binding
EC50 ~ 2.5 - 5 ?M in activation of ERK1/2 in rat arterial smooth muscle and Rat2 cells
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

序列

Myr-N-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp-OH

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C93H150N20O25
分子量	1948.31

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	lyophilized
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic)
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable