半岛bd体育手机客户端 说明

一般描述

A peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker of viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Also shown to reduce the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
A peptidyl chloromethylketone that binds irreversibly to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Completely inhibits the cleavage of Boc-RVRR-AMC (50 ?M) by purified furin or PACE4. Also inhibits the activity of endothelin converting enzyme and reduces the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).

包装

1 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
viral glycoproteins

警告

Toxicity: Standard Handling (A)

序列

Decanoyl-Arg-Val-Lys-Arg-CMK

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Sugrue, R.J., et al. 2001.J. Gen. Virol.82,1375.
Wang, X., and Pei, D. 2001.J. Biol. Chem.276,35953.
Capell, A., et al. 2000.J. Biol. Chem.275,30849.
Denault, J.B., et al. 1995.FEBS Lett.362,276.
Denault, J.B., et al. 1995.J. Cardiovasc. Pharmacol.26,S47.
Garten, W., et al. 1994.Biochimie76,217.
Hallenberger, S., et al. 1992.Nature360,358.
Stieneke-Gr?ber, A., et al. 1992.EMBO J.11,2407.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C34H66ClN11O5
分子量	744.41

半岛bd体育手机客户端 性质

质量水平	100
测定	≥90% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated
颜色	off-white
溶解性	methanol: 1 mg/mL DMSO: soluble
运输	ambient
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable