半岛bd体育手机客户端 说明
一般描述
A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 ?g/76 ?l) solution of Z-IETD-FMK (Cat. No. 218840) in DMSO is also available.
A potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.
包装
250 μg in Glass bottle
1 mg in Plastic ampoule
生化/生理作用
Primary Target
caspase-8
Product does not compete with ATP.
Cell permeable: yes
Reversible: no
警告
Toxicity: Standard Handling (A)
序列
Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH?F*
重悬
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.
分析说明
single spot by TLC
其他说明
Takizawa, T., et al. 1999.Microbiol. Immunol.43,245.
Martin, D.A., et al. 1998.J. Biol. Chem.273,4345.
Sweeney, E.A., et al. 1998.FEBS Lett.425,61.
Thornberry, N.A., and Lazebnik, Y. 1998.Science281,1312.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C30H43FN4O11 |
| 分子量 | 654.68 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 形式 | powder |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated |
| 颜色 | white to yellow |
| 溶解性 | DMSO: 10 mM |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
