半岛bd体育手机客户端 说明
一般描述
A potent, specific, and reversible inhibitor of caspase-1 (Ki= 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.
Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. ICE inhibitor I is a potent, specific, and reversible inhibitor of ICE (Ki= 200 pM for human recombinant ICE). Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.
包装
1, 5 mg in Plastic ampoule
生化/生理作用
Target Ki: 200 pM for human recombinant caspase-1
Product does not compete with ATP.
Cell permeable: no
Reversible: yes
Primary Target
caspase-1, human recombinant
警告
Toxicity: Standard Handling (A)
序列
Ac-Tyr-Val-Ala-Asp-CHO
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Garcia-Calvo, M., et al. 1998.J. Biol. Chem.273,32608.
Hilbi, H., et al. 1998.J. Biol. Chem.273,32895.
Thornberry, N.A., and Lazebnik, Y. 1998.Science281,1312.
Los, M., et al. 1995.Nature375,81.
Walker, N.P.C., et al. 1994.Cell78,343.
Wilson, K.P., et al. 1994.Nature370,270.
Thornberry, N.A., et al. 1992.Nature356,768.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C23H32N4O8 |
| 分子量 | 492.52 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | powder |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | white |
| 溶解性 | DMSO: 5 mg/mL water: soluble |
| 运输 | ambient |
| 储存温度 | ?20℃ |
| InChI | 1S/C23H32N4O8/c1-12(2)20(23(35)27-21(33)13(3)24-16(11-28)10-19(31)32)26-22(34)18(25-14(4)29)9-15-5-7-17(30)8-6-15/h5-8,11-13,16,18,20,24,30H,9-10H2,1-4H3,(H,25,29)(H,26,34)(H,31,32)(H,27,33,35)/t13-,16-,18-,20-/m0/s1 |
| InChI key | KQCBPHUOVBKBPQ-SJVNDZIOSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
