ADP-HPD, Dihydrate, Ammonium Salt-Calbiochem

半岛bd体育手机客户端 说明

一般描述

An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC₅₀= 120 nM) vs. ADP-ribose (IC₅₀= 120 mM). Also inhibits NAD glycohydrolase fromBungarus fasciatusvenom at much higher concentrations (IC₅₀= 260 ?M). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration.
An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC₅₀= 120 nM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration. Also acts as an inhibitor of NAD glycohydrolase fromBungarus fasciatusvenom at much higher concentrations (IC₅₀= 260 ?M). Note: 1 set = 5 x 60 ?g.
Note: 1 set = 5 x 60 ?g

包装

60 μg in Plastic ampoule
1 set in Glass bottle
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Primary Target
PARG
Reversible: no
Target IC₅₀: 120 nM against poly(ADP-ribose) glycohydrolase (PARG)
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.

其他说明

Vispe, S., et al. 2000.Proc. Natl. Acad. Sci. USA97,9886.
Slama, J.T., et al. 1995.J. Med. Chem.38,389.
Slama, J.T., et al. 1995.J. Med. Chem.38,4332.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C15H23N6O12P2· NH4· 2H2O
分子量	595.39

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	lyophilized solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic) protect from light
颜色	white
溶解性	water: 5 mg/mL
运输	ambient
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable