sphinganine-d7

半岛bd体育手机客户端 说明

一般描述

Sphinganine-d7 is a deuterated derivative of sphinganine. Sphinganine, also called as dihydrosphingosine is a derivative of sphingosine. Sphinganines are produced in endoplasmic reticulum, by decarboxylating condensation of palmitoyl-CoA and serine.

应用

Sphinganine-d7 has been used as an internal standard for quantification of sphingolipid concentrations in plasma and tissue samples by high-performance liquid chromatography tandem mass spectrometry.

生化/生理作用

Sphinganine (SPA) acts as a selective inhibitor of protein kinase C in intact human neutrophils. It may function a potential biomarker for the diagnosis of sphingolipidoses. SPA accumulation enables fumonisin B1 to stimulate apoptosis. It also has an ability to block cholesterol transport in Niemann-Pick Type C (NPC) disease.

包装

5 mL Amber Glass Screw Cap Vial (860658P-1mg)

基本信息

经验(实验)分子式	C18H32D7NO2
分子量	308.55
NACRES	NA.25

半岛bd体育手机客户端 性质

形式	powder
包装	pkg of 1 × 1 mg (860658P-1mg)
manufacturer/tradename	Avanti Polar Lipids 860658P
运输	dry ice
储存温度	?20℃
SMILES string	OC[C@@](N)([H])[C@@](O)([H])CCCCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]

安全信息

储存分类代码

13 - Non Combustible Solids