Phospho-Stat1 (pSer⁷²⁷) and pan-Stat1 ELISA Kit

半岛bd体育手机客户端 说明

一般描述

The Phospho-Stat1 (pSer⁷²⁷) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.

免疫原

Stat1 (pTyr⁷²⁷) synthetic phosphopeptide, Recombinant Human STAT1

应用

请参考Protocol了解详情。

生化/生理作用

Signal transducer and activator of transcription 1 (STAT1) undergoes phosphorylation on serine-727. This Phospho-Stat1 regulates pro- and anti-apoptotic genes following several stress-induced responses. STAT-1 interacts with p53 and promotes p53-mediated transcriptional gene activity and apoptosis. STAT-1 is an essential factor of stress-induced and DNA damage-induced checkpoint pathways and thus, acts as a tumour suppressor. STAT-1 functions as a pro-apoptotic factor in cardiac myocytes, brain or liver exposed to ischaemia–reperfusion injury. Thus, inhibition of STAT-1-activated pathway by epigallocatechin-3-gallate (EGCG), can be considered as a potential therapeutic method against ischaemic tissue injury. Repression of STAT-1 expression by human papillomavirus (HPV) oncoproteins E6 and E7 at transcription level is essential for genome amplification and maintenance of episomes, which is suggested to have a crucial role in viral pathogenesis.

基本信息

NACRES

NA.32

半岛bd体育手机客户端 性质

species reactivity	human, mouse
technique(s)	ELISA: suitable capture ELISA: suitable
运输	wet ice
储存温度	?20℃
Gene Information	human ... STAT1(6772) mouse ... STAT1(20846)

安全信息

象形图
警示用语：	Warning
危险声明	H290 - H335
危险分类	Met. Corr. 1 - STOT SE 3
靶器官	Respiratory system
储存分类代码	8B - Non-combustible, corrosive hazardous materials