Nilutamide

半岛bd体育手机客户端 说明

应用

Nilutamide has been used:

• as a nuclear androgen receptor (nAR) inhibitor to study its effects on oocyte maturation in zebrafish
• to determine its effects on bioluminescentSaccharomyces cerevisiaebioreporters in BLYAS assay
• as a substrate in hydrogenation reaction

包装

1 g in glass bottle

生化/生理作用

Nilutamide is a nuclear androgen receptor inhibitor. It is a nonsteroidal antiandrogen that competitively inhibits the binding of dihydrotestosterone to the androgen receptor. Nilutamide shows a therapeutic effect against prostate cancer.

特点和优势

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

其他说明

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. N8534.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

基本信息

经验(实验)分子式	C12H10F3N3O4
分子量	317.22
MDL编号	MFCD00864670
PubChem化学物质编号	24278596
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	200
形式	solid
创始人	Sanofi Aventis
SMILES string	CC1(C)NC(=O)N(c2ccc(c(c2)C(F)(F)F)[N+]([O-])=O)C1=O
InChI	1S/C12H10F3N3O4/c1-11(2)9(19)17(10(20)16-11)6-3-4-8(18(21)22)7(5-6)12(13,14)15/h3-5H,1-2H3,(H,16,20)
InChI key	XWXYUMMDTVBTOU-UHFFFAOYSA-N
Gene Information	human ... AR(367)

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H360
预防措施声明	P201 - P301 + P310 + P330
危险分类	Acute Tox. 3 Oral - Repr. 1B
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges