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位置: 首页> 品牌> Sigma-Aldrich> MDR1/BCRP Double Knockout Caco-2 Cells

MDR1/BCRP Double Knockout Caco-2 Cells

品牌
Sigma-Aldrich
货号
MTOX1004
包装型号
规格纯度
one vial
价格
25360.6 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
MDR1/BCRP Double Knockout Caco-2 Cells
C2BBe1 Cells MDR1/BCRP (-/-/-/-,-/-/-/-)
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The C2BBe1 cells, a subclone of Caco-2 cells, correspond to ATCC CRL-2102. The MDR1 and BCRP knockout C2BBe1 cells are adenocarcinoma, epithelial cells from a human caucasian male (aged 72 years) with functional knockout of the ABCB1 and ABCG2 (MDR1/BCRP) efflux transporters.

应用

The following posters and articles demonstrate how Caco-2 cells can be used for cell based assays:

Transporter Function in Caco-2 Cells with Targeted P-Glycoprotein, MRP2 and BCRP Gene Knockout Using Zinc Finger Nucleases

Comparison of Function and Relative Transporter Protein Concentrations in Caco-2 Cells with Single and Double Knockouts of the ABCB1, ABCG2, and ABCC2 Genes

Caco-2 Transporter Knockout Cell Based Assays

特点和优势

The Caco-2 subclone C2BBe1 cells are ideal for transporter analysis as they express multiple transporters, are human derived, and grow in a homogenous monolayer that forms tight junctions necessary for efflux ratio analysis. Other benefits include:

  • A functional double knockout of the MDR1 gene and BCRP gene eliminates the reliance on chemical inhibitors to determine if a compound is an MRP2 substrate
  • The vial format enables the MDR1 and BCRP knockout cells to be included in standard drug transporter protocols
  • Human assay with no interference from animal inhibitors
  • Overcome the limitations of RNAi and knockdown cell lines that arise from remaining transporter functionality

法律信息

ADME/Tox Cell Lines License

基本信息

NACRES NA.81

半岛bd体育手机客户端 性质

质量水平 200
生物来源 human male colorectal tissue (Source disease: adenocarcinoma)
形式 liquid
technique(s) drug transporter assay: suitable
permeability assay: suitable
OMIM登记号 171050
603756
application(s) ADME/TOX
储存温度 ?196℃
Gene Information human ... ABCB1(5243), ABCG2(9429)

组份列表

组份可单独销售

货号 组份
MTOX1004 MDR1/BCRP Double Knockout Caco-2 Cells, one vial 1 vial

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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