半岛bd体育手机客户端 说明
一般描述
The C2BBe1 cells, a subclone of Caco-2 cells, correspond to ATCC CRL-2102. The MDR1 and BCRP knockout C2BBe1 cells are adenocarcinoma, epithelial cells from a human caucasian male (aged 72 years) with functional knockout of the ABCB1 and ABCG2 (MDR1/BCRP) efflux transporters.
应用
The following posters and articles demonstrate how Caco-2 cells can be used for cell based assays:
Transporter Function in Caco-2 Cells with Targeted P-Glycoprotein, MRP2 and BCRP Gene Knockout Using Zinc Finger Nucleases
Comparison of Function and Relative Transporter Protein Concentrations in Caco-2 Cells with Single and Double Knockouts of the ABCB1, ABCG2, and ABCC2 Genes
Caco-2 Transporter Knockout Cell Based Assays
特点和优势
The Caco-2 subclone C2BBe1 cells are ideal for transporter analysis as they express multiple transporters, are human derived, and grow in a homogenous monolayer that forms tight junctions necessary for efflux ratio analysis. Other benefits include:
法律信息
ADME/Tox Cell Lines License
基本信息
NACRES | NA.81 |
半岛bd体育手机客户端 性质
质量水平 | 200 |
生物来源 | human male colorectal tissue (Source disease: adenocarcinoma) |
形式 | liquid |
technique(s) | drug transporter assay: suitable permeability assay: suitable |
OMIM登记号 | 171050 603756 |
application(s) | ADME/TOX |
储存温度 | ?196℃ |
Gene Information | human ... ABCB1(5243), ABCG2(9429) |
组份列表
组份可单独销售
货号 | 组份 |
MTOX1004 | MDR1/BCRP Double Knockout Caco-2 Cells, one vial 1 vial |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich