desmosterol-d6

半岛bd体育手机客户端 说明

一般描述

Desmosterol constitutes 1% of brain sterol and is catabolized to cholesterol by the enzyme 3-hydroxysterol 24-reductase (DHCR24). It is an intermediate in the Bloch branch of the cholesterol biosynthesis pathway. Desmosterol-d6 is a deuterated form of desmosterol.

应用

Desmosterol-d6 has been used:

• as a deuterated standard in liquid chromatography multiple reaction monitoring (LC-MRM)
• as a deuterated standard in high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS)
• for spiking brain tissue homogenate from Alzheimer′s disease (AD) for liquid chromatography -mass spectrometry (LC-MS) analysis

生化/生理作用

Desmosterol low levels in the hippocampus directly impacts progenitor cell differentiation into neurons. Desmosterol-d6 is used as a substitute to desmosterol in hepatitis C virus (HCV) based viral assays to rescue replication. Desmosterol being a C27 sterol intermediate is implicated in the Alzheimer′s disease (AD) pathogenesis.

包装

5 mL Amber Glass Screw Cap Vial (700040P-1mg)

基本信息

经验(实验)分子式	C27H38OD6
分子量	390.67
NACRES	NA.25

半岛bd体育手机客户端 性质

测定	>99% (TLC)
形式	powder
包装	pkg of 1 × 1 mg (700040P-1mg)
manufacturer/tradename	Avanti Polar Lipids 700040P
运输	dry ice
储存温度	?20℃

安全信息

储存分类代码

13 - Non Combustible Solids