cholestenoic acid-d5

半岛bd体育手机客户端 说明

一般描述

Cholestenoic acid-d5 is an endogenous cholesterol metabolite. It is produced in extrahepatic organs.
Cholestenoic acid levels in plasma ranges between 100-300 nM and is synthesized in brain. Cholestenoic acid is generated by the side chain oxidation of 27-hydroxy-cholesterol and is an intermediate in the bile synthesis pathway.

生化/生理作用

Cholestenoic acid-d5 functions as a potent steroid γ-secretase modulator (GSM).
Cholestenoic acid is a carboxylic acid γ-secretase modulator. Cholestenoic acid also serves as a ligand for liver X receptor. Cholestenoic acid -d5 regulates amyloid β peptides (Aβ) levels. It reduces Aβ42 levels and enhances Aβ38 levels. In retina, it is the major byproduct of cholesterol elimination. 27-hydroxycholesterol and cholestenoic acid are part of reverse cholesterol transport in macrophages and their transport impairment is implicated in premature atherosclerosis.

包装

5 mL Amber Glass Screw Cap Vial (700151P-1mg)

基本信息

经验(实验)分子式	C27H39D5O3
分子量	421.67
NACRES	NA.25

半岛bd体育手机客户端 性质

测定	>99% (TLC)
形式	powder
包装	pkg of 1 × 1 mg (700151P-1mg)
manufacturer/tradename	Avanti Polar Lipids 700151P
运输	dry ice
储存温度	?20℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3