C18 LPA

半岛bd体育手机客户端 说明

一般描述

Lysophosphatidic acid (LPA) is a class of phospholipids, which is water-soluble. It has a glycerol backbone attached via a phosphate group, an aliphatic chain and a hydroxyl group. The aliphatic chain is linked to eithersn-1 orsn-2 position and the phosphate group is connected to thesn-3 position. The hydroxyl group is linked to the remainingsn-1 orsn-2 position.

应用

C18 LPA or 1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate may be used:

• to study its effects on Yes-associated protein (YAP) phosphorylation
• as a standard for the quantification of lysophosphatidic acid (LPA) compounds in proton samples using reversed-phase ultra-performance liquid chromatography-tandem mass spectrometer (UPLC-MS/MS)
• as a substrate to investigate the phosphatase activity of soluble epoxide hydrolase (sEH) towards LPA compounds

生化/生理作用

Lysophosphatidic acid (LPA) is a signaling molecule and alters various cellular responses through G protein-coupled receptors (GPCRs). It stimulates smooth muscle contraction, cytoskeleton rearrangement and chemotaxis. LPA is also involved in inducing neurotransmitter release, cell proliferation, platelet aggregation and Ca²⁺mobilization. Increased levels of LPA in human plasma leads to ovarian cancer and atherosclerosis. LPA acts as a potential biomarker for ovarian cancer.

包装

5 mL Amber Glass Screw Cap Vial (857228P-1mg)

基本信息

经验(实验)分子式	C21H48NO6P
分子量	441.58
NACRES	NA.25

半岛bd体育手机客户端 性质

测定	>99% (LPA; may contain up to 10% of the 2-LPA isomer)
形式	powder
包装	pkg of 1 × 1 mg (857228P-1mg)
manufacturer/tradename	Avanti Polar Lipids 857228P
运输	dry ice
储存温度	?20℃
SMILES string	O[C@](COP([O-])(O)=O)([H])COCCCCCCCCCCCCCCCCCC.[NH4+]

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3