C-Peptide EIA Kit

半岛bd体育手机客户端 说明

一般描述

The C-Peptide Enzyme Immunoassay (EIA) Kit is an in vitro quantitative assay for detecting C-Peptide peptide based on the principle of Competitive Enzyme Immunoassay. EIA-CPE-1 only detects C-peptide, not Insulin A or B chain.

免疫原

C-Peptide , synthetic peptide

应用

请参考Protocol了解详情。

生化/生理作用

C-peptide inhibits endothelial dysfunction under high glucose conditions via inhibition of nuclear factor-κB (NF-κB) pathway. Experimental studies suggest that prolonged dosage of physiological concentration of C-peptide to type 1 diabetes patients minimizes diabetes-induced complications, such as glomerular hypertrophy and mesangial matrix expansion by interrupting transforming growth factor β1 (TGF-β1) and tumor necrosis factor α (TNFα) signaling pathway. C-peptide reduces diabetes-induced glomerular hyperfiltration by contraction of the afferent arteriole, dilation of the efferent arteriole, and by inhibition of tubular reabsorption. C-Peptide also plays a crucial role in renal pathophysiology. C-peptide binds to a cell surface receptor that is likely to be G-protein coupled. This interaction stimulates various cellular functions such as increasing intracellular Ca²⁺concentration, enhancing PI3-K (phosphoinositide 3-kinase) activity, increased endothelial nitric oxide synthase (eNOS) transcription, and activation of the Na⁺/K⁺ATPase and mitogen-activated protein kinase (MAPK) signaling pathway.

基本信息

NACRES

NA.32

半岛bd体育手机客户端 性质

species reactivity	human, rat, mouse
包装	kit of 96 wells (12 strips x 8 wells)
technique(s)	ELISA: suitable enzyme immunoassay: suitable
input	sample type cell lysate sample type culture supernatant(s) sample type plasma sample type serum
assay range	inter-assay cv: <15% intra-assay cv: <10% sensitivity: 772 pg/mL standard curve range: 0.1-1000 ng/mL
detection method	colorimetric
运输	wet ice
储存温度	?20℃
Gene Information	human ... INS(3630)

组份列表

组份可单独销售

货号	组份
RABHRP3	HRP-Streptavidin

安全信息

象形图
警示用语：	Warning
危险声明	H290
预防措施声明	P234 - P390
危险分类	Met. Corr. 1
储存分类代码	8A - Combustible, corrosive hazardous materials
WGK	WGK 3