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位置: 首页> 品牌> Sigma-Aldrich> AHCY Inhibitor Screening Kit (Fluorometric)

AHCY Inhibitor Screening Kit (Fluorometric)

品牌
Sigma-Aldrich
货号
EPI022
规格纯度
sufficient for 100 fluorometric tests
价格
12667.3 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
AHCY Inhibitor Screening Kit (Fluorometric)
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Adenosyl homocysteinase (AHCY) (EC 3.3.1.1) or S-adenosyl homocysteine hydrolase (SAHH); is an enzyme that catalyzes the reversible hydrolysis of S-Adenosyl Homocysteine (SAH) to adenosine and homocysteine. Inhibition of AHCY results in the accumulation of SAH, a product inhibitor of S-adenosyl methionine (SAM)-dependent methyltransferases. AHCY is an important target as an antiviral and anticancer drug. Several characterized SAH inhibitors inhibit some DNA viruses (e.g. Pox viruses) and some negative stranded RNA viruses (e.g.: Marburg virus, Ebola virus & rabies).

适用性

Suitable for screening, characterizing and studying AHCY inhibitors

原理

In this AHCY Inhibitor Screening kit the homocysteine generated from the breakdown of SAH is measured using a Thiol Detecting Reagent resulting in enhanced fluorescence (λex= 392 nm/λem= 482 nm). The AHCY reaction is reversible and hence adenosine deaminase is included in the reaction to ensure the reaction proceeds towards hydrolysis of SAH. In the presence of AHCY inhibitor, there is a decrease in fluorescence of the Thiol Detecting Reagent.

基本信息

NACRES NA.25

半岛bd体育手机客户端 性质

质量水平 100
用途 sufficient for 100 fluorometric tests
detection method fluorometric
储存温度 ?20℃

安全信息

象形图 GHS05GHS07GHS08
警示用语: Danger
危险声明 H312 - H317 - H318 - H334 - H361d - H412
预防措施声明 P202 - P273 - P280 - P302 + P352 + P312 - P305 + P351 + P338 - P308 + P313
危险分类 Acute Tox. 4 Dermal - Aquatic Chronic 3 - Eye Dam. 1 - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
储存分类代码 10 - Combustible liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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