半岛bd体育手机客户端 说明

一般描述

5α,6α-epoxycholestanol (5α,6α-EC) is generated by cholesterol epoxidation. 5α,6α-epoxycholestanol-d7 is a deuterated derivative of 5α,6α-EC. It is catabolized by the enzyme cholesterol-5,6-epoxide hydrolase (ChEH) enzyme to 3β,5α,6β-triol.

应用

5α,6α-epoxycholestanol-d7 has been used as an internal standard in isotope dilution-mass spectrometry analysis of heart mitochondrial samples. It may be used as an internal standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis of plasma samples.

生化/生理作用

5α,6α-epoxycholestanol (5α,6α-EC) is a liver X receptor (LXR) antagonist. 5α,6α-EC is employed in anticancer treatments. It impairs redox state and affects atherogenesis. The levels of 5α,6α-EC are elevated in hypercholesterolemia. It mediates steroid receptor coactivator (SRC) recruitment.

包装

5 mL Amber Glass Screw Cap Vial (700047P-1mg)

基本信息

经验(实验)分子式	C27H39O2D7
分子量	409.70
NACRES	NA.25

半岛bd体育手机客户端 性质

测定	>99% (TLC)
形式	powder
包装	pkg of 1 × 1 mg (700047P-1mg)
manufacturer/tradename	Avanti Polar Lipids 700047P
运输	dry ice
储存温度	?20℃

安全信息

储存分类代码

13 - Non Combustible Solids