半岛bd体育手机客户端 说明
一般描述
4-Hydroxyphenylpyruvate Dioxygenase (4-HPPD) is a key enzyme in the catabolism of tyrosine and phenylalanine. 4-HPPD catalyzes the synthesis of homogenistate (2,5-dihydroxyphenylacetate) from ρ-hydroxyphenylpyruvate and molecular oxygen. 4-HPPD also catalyzes the conversion of α-ketoisocaproate to Β-hydroxyisovalerate. 4-HPPD requires Fe2+as an essential cofactor.
Rat 4-HPPD has a minimum of 80% homology with human 4-HPPD. Rat 4-HPPD is expressed abundantly in hepatocytes. It is also expressed in kidney, particularly in epithelial cells of the proximal tubules and the distant tubules. 4-HPPD has been identified as a potential biomarker of drug-induced liver injury in rat studies.
单位定义
One unit will oxidize 1 μmole of molecular oxygen per minute at pH 7.0, 25 ℃, in the presence of 4-hydroxyphenylpyruvate.
基本信息
| 酶学委员会(EC)编号 | 1.13.11.27 ( BRENDA | IUBMB ) |
| NACRES | NA.54 |
半岛bd体育手机客户端 性质
| 质量水平 | 200 |
| 重组 | expressed inE. coli |
| 形式 | liquid |
| specific activity | ≥5 U/mg |
| 分子量 | ~41.8 kDa |
| 运输 | dry ice |
| 储存温度 | ?70℃ |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
