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THI

品牌
Avanti
CAS
94944-70-4
货号
857393P
规格纯度
2-acetyl-5-tetrahydroxybutyl imidazole, powder
价格
2215.34 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
94944-70-4
THI
2-acetyl-4-tetrahydroxybutyl imidazole; 2-acetyl-4(5)-tetrahydroxybutyl imidazole; 2-ATHBI
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. 2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of S1P lyase. Because S1P lyase is primarily expressed in lymphatic tissue, treatment of mice with THI (50 μg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs. The resulting lymphopenia is reversible following cessation of THI treatment. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.
2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of sphingosine-1-phosphate lyase (S1P lyase).

生化/生理作用

2-Acetyl-5-tetrahydroxybutyl imidazole (THI) can block S1P lyasein vivoand up-regulates circulatory and tissue S1P levels. It has the ability to repress dystrophic muscle degeneration.

包装

5 mL Amber Glass Screw Cap Vial (857393P-1mg)

基本信息

经验(实验)分子式 C9H14N2O5
分子量 230.22
NACRES NA.25

半岛bd体育手机客户端 性质

测定 >98% (TLC)
形式 powder
包装 pkg of 1 × 1 mg (857393P-1mg)
manufacturer/tradename Avanti Polar Lipids 857393P
运输 dry ice
储存温度 ?20℃
InChI 1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1
InChI key CQSIXFHVGKMLGQ-BWZBUEFSSA-N

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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