Nogo-66(1-40) antagonist peptide

半岛bd体育手机客户端 说明

Amino Acid Sequence

Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH2

应用

Nogo-66(1-40) antagonist peptide has been used as a Nogo-66 receptor antagonist peptide:

• to study the preliminary therapeutic effect after inhibition of Nogo-A in the cauda equina compression (CEC) model
• to determine the effects of Nogo-A/NgR1 on autophagic activation
• to study its role in Nogo-B mediated axonal branching using Schwann cells and sensory neurons of mice

包装

1 mg in glass bottle

生化/生理作用

Myelin-derived axon outgrowth inhibitors, such as Nogo, may account for the lack of axonal regeneration in the central nervous system (CNS) after trauma in adult mammals. Nogo-66 can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR). Competitive antagonists of NgR derived from amino-terminal peptide fragments of Nogo-66. The Nogo-66(1 40) antagonist peptide (NEP1 40) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowthin vitro,demonstrating that NgR mediates a significant portion of axonal outgrowth inhibition by myelin. Intrathecal administration of NEP1 40 to rats with mid-thoracic spinal cord hemisection results in significant axon growth of the corticospinal tract, and improves functional recovery. Thus, Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and NEP1-40 provides a potential therapeutic agent.

法律信息

Sold under a non-exclusive license. For research use only, and not for diagnostic or therapeutic use or for use in humans.

基本信息

经验(实验)分子式	C204H322N56O64· xC2HF3O2
分子量	4583.08 (free base basis)
MDL编号	MFCD06411437
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	100
测定	≥84% (HPLC)
形式	lyophilized solid
颜色	white
溶解性	H2O: 1 mg/mL
UniProt登记号	Q9NQC3
储存温度	?20℃
Gene Information	human ... RTN4(57142)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)