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位置: 首页> 品牌> Sigma-Aldrich> N-Acetyl-Glu-Ser-Met-Asp-al

N-Acetyl-Glu-Ser-Met-Asp-al

品牌
Sigma-Aldrich
CAS
191338-87-1
货号
A1341
规格纯度
≥90% (HPLC), powder
价格
3160.26 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
191338-87-1
N-Acetyl-Glu-Ser-Met-Asp-al
Ac-ESMD-CHO
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

N-Acetyl-Glu-Ser-Met-Asp-aldehyde (Ac-ESMD-CHO) is a tetrapeptide analog that act to inhibit the activity of caspase-3 and caspase-7 proteins, which are involved in apoptosis. Ac-ESMD-CHO has been shown to block formation of the caspase-3 p17 and p12 subunits, induce accumulation of the p20 precursor peptide, inhibit 25-hydroxycholesterol-induced apoptosis in rat Sertoli cells and also to bind caspase-7.

包装

1 mg in glass bottle

生化/生理作用

In the caspase-3 precursor, procaspase-3, the ESMD amino acid sequence has been identified as a cleavage site for producing the p17 and p12 subunits of mature caspase 3; Ac-ESMD-CHO has been shown to inhibit the protease that cleaves procaspase-3 at this site. Ac-ESMD-CHO binds caspase-7 and inhibits with a Kiof approximately 1300 nM, which makes it a weaker inhibitor than other inhibitor tetrapeptide analogs.

基本信息

经验(实验)分子式 C19H30N4O10S
分子量 506.53
MDL编号 MFCD01318859
PubChem化学物质编号 329770361
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 200
测定 ≥90% (HPLC)
形式 powder
颜色 white
溶解性 H2O: 1 mg/mL
储存温度 ?20℃
SMILES string CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C=O
InChI 1S/C19H30N4O10S/c1-10(26)20-12(3-4-15(27)28)18(32)23-14(9-25)19(33)22-13(5-6-34-2)17(31)21-11(8-24)7-16(29)30/h8,11-14,25H,3-7,9H2,1-2H3,(H,20,26)(H,21,31)(H,22,33)(H,23,32)(H,27,28)(H,29,30)/t11-,12-,13-,14-/m0/s1
InChI key TVTYMGFOGZRIHG-XUXIUFHCSA-N

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, type N95 (US)

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