MMP Substrate

半岛bd体育手机客户端 说明

Amino Acid Sequence

MCA-Lys-Pro-Leu-Gly-Leu-DNP-Dpa-Ala-Arg-NH2

一般描述

Matrix Metalloproteases (MMPs) belongs to the zinc metalloprotease family M10. They are zinc-dependent, calcium-containing hydrolases.

生化/生理作用

Matrix Metalloproteases (MMPs) are involved in extracellular matrix (ECM) degradation. MMPs regulate cellular and disease processes. They are implicated in processes such as cell proliferation, migration, differentiation, angiogenesis, anti-inflammatory response, vasoconstriction, apoptosis and host defense. Dysregulation of MMP is associated with arthritis, ulcers, encephalomyelitis and cancer.
The peptide MCA-Lys-Pro-Leu-Gly-Leu-DNP-Dpa-Ala-Arg-NH2, or FS-6, is a fluorogenic substrate for several matrix metalloproteinases (MMPs). FS-6 is a water-soluble, modified form of the well-established MMP substrate FS-1, where a lysine residue has been added to the N-terminus of FS-1. The resulting FS-6 has been reported to give a peptide with improved kinetic properties for several MMPs, including MMP-1, MMP-8, MMP-13, and MMP-14, compared to FS-1. This MMP substrate has also been described as a particularly useful substrate for the zinc metalloproteinase tumor necrosis factor-α converting enzyme (TACE or ADAM-17). FS-6 can be used to measure metalloproteinase activity in tissue culture conditions, for example, on the surface of viable cellsinsitu.

基本信息

经验(实验)分子式	C55H80N16O16
分子量	1221.32
NACRES	NA.32

半岛bd体育手机客户端 性质

测定	≥95% (HPLC)
形式	lyophilized
组成	Peptide Content, ≥75%
储存条件	protect from light
储存温度	?20℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable