Kdo2-Lipid A (KLA)

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一般描述

Kdo2-Lipid A is a natural endotoxin and a combination of oligosaccharide and lipid.
A new preparation of the saccharolipid glycan, Kdo2-Lipid A (KLA), is a nearly homogeneous Re lipopolysaccharide (LPS) substructure with endotoxin activity equal to that of native LPS. KLA is comparable to LPS and its activity is reduced by >103 in cells from TLR-4 deficient mice. The advantage of KLA over LPS is that it is a reproducible, defined natural product, and it can be detected by ESI/MS at the low concentrations used to stimulate animal cells. The purity of KLA should also facilitate the structural analysis of its complexes with signaling receptors, such as TLR-4/MD2. New research* shows 1μg KLA induces the same response as 10μg LPS.Perform experiments at half the cost of using LPS!

应用

Kdo2-Lipid A (KLA) has been used:

• as a toll like receptor (TLR) ligand source in immortalized murine macrophage culture media
• in²H-,¹³C-,¹⁵N-labeled OprHΔL1ΔL4 in 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC) micelles, to determine the specific residues of OprHΔL1ΔL4 interacting with lipopolysaccharides (LPS) source
• as a component of LPS stock to study its role in lipopolysaccharide induced prion protein conversion

Kdo2-Lipid A (KLA) has been used to study its role in lipopolysaccharide induced prion protein conversion.

生化/生理作用

Kdo2-Lipid A might be useful to stimulate inflammatory response.

包装

2 mL Amber Glass Crimp Cap Vial (699500P-1mg)

其他说明

For R&D use only. Not for drug, household, or other uses.

基本信息

NACRES

NA.25

半岛bd体育手机客户端 性质

测定	>99% (HPLC)
形式	powder
包装	pkg of 1 × 1 mg (699500P-1mg)
manufacturer/tradename	Avanti Polar Lipids 699500P
运输	dry ice
储存温度	?20℃
SMILES string	O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO[C@]2(C([O-])=O)C[C@@H](O[C@@]3(C([O-])=O)O[C@H]([C@H](O)CO)[C@H](O)[C@H](O)C3)[C@@H](O)[C@@H]([C@H](O)CO)O2)[C@@H](OP([O-])(O)=O)[C@@H]1OC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCC

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	No data available
闪点(C)	No data available