27-hydroxycholesterol-d6

半岛bd体育手机客户端 说明

一般描述

27-hydroxycholesterol (27-HC) is synthesized from cholesterol by the action of sterol 27-hydroxylase in the liver. It is an abundant oxysterol in the circulation ranging from 0.15 to 0.73 μM. 27-HC serves as a substrate for bile synthesis. 27-hydroxycholesterol-d6 is a deuterated form of 27-hydroxycholesterol.

应用

27-hydroxycholesterol-d6 has been used:

• as an internal standard in isotope dilution-mass spectrometry analysis of heart mitochondria samples
• as an internal standard in gas chromatography-mass spectrometry (GC–MS) for plasma sterol quantification
• as a deuterated internal standard for spiking plasma samples for liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis

生化/生理作用

27-hydroxycholesterol (27-HC) is a weak liver X receptor (LXR) agonist and a selective estrogen receptor modulator (SERM). Elevated levels of 27-HC is observed in hypercholesterolemia. 27-HC is implicated in breast cancer tumor and glioblastoma progression. 27-HC may help in treating non-alcoholic steatohepatitis. Elevated levels of 27-HC is associated with atherosclerotic lesions.

包装

5 mL Amber Glass Screw Cap Vial (700059P-1mg)

基本信息

经验(实验)分子式	C27H40D6O2
分子量	408.69
NACRES	NA.25

半岛bd体育手机客户端 性质

测定	>99% (TLC)
形式	powder
包装	pkg of 1 × 1 mg (700059P-1mg)
manufacturer/tradename	Avanti Polar Lipids 700059P
运输	dry ice
储存温度	?20℃
SMILES string	[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC[C@@]([2H])(C([2H])([2H])[2H])C(O)([2H])[2H]

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	No data available
闪点(C)	No data available