1-desoxymethylsphinganine

半岛bd体育手机客户端 说明

一般描述

1-desoxymethylsphinganine is synthesized by the condensation of alanine with palmitoyl-CoA.

应用

1-desoxymethylsphinganine is suitable for use for testing its cytotoxic effects on primary neuron-glia cultures. It is also suitable for use as a neurotoxic agent in human CD8⁺T cells. In hereditary sensory and autonomic neuropathy type I, mutations in serine palmitoyltransferase long chain base subunit 1 resulting in altered substrate specificity and accumulation of 1.

生化/生理作用

1-desoxymethylsphinganine is neurotoxic towards CD8⁺T cells and inhibits cytokine production. However, it is not cytotoxic to dopaminergic neurons.

包装

5 mL Amber Glass Screw Cap Vial (860473P-1mg)

基本信息

经验(实验)分子式	C17H37NO
分子量	271.48

半岛bd体育手机客户端 性质

形式	powder
包装	pkg of 1 × 1 mg (860473P-1mg)
manufacturer/tradename	Avanti Polar Lipids 860473P
运输	dry ice
储存温度	?20℃
SMILES string	NC[C@]([H])(O)CCCCCCCCCCCCCCC

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3