Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone

半岛bd体育手机客户端 说明

Amino Acid Sequence

Z-Ile-Glu-OMe-Thr-Asp-OMe-FMK

应用

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor:

• to study the activity of caspase-8 in porcine kidney cells
• to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells
• to study its effects on retinal ganglion and astroglia in rat eyes

生化/生理作用

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.

特点和优势

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C30H43FN4O11
分子量	654.68
MDL编号	MFCD01861686
PubChem化学物质编号	329774744
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	200
生物来源	synthetic (organic)
测定	≥90% (TLC)
形式	powder
溶解性	methanol: 10 mg/mL DMSO: 20 mM, clear, colorless to light yellow
运输	dry ice
储存温度	?20℃
SMILES string	CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF
InChI	1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1
InChI key	CTXDBLYOEUERAT-VUVYEONESA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)