Ro-31-7549, Monohydrate-CAS 125313-65-7-Calbiochem

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一般描述

A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC₅₀= 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ₁. Exhibits some degree of PKC isozyme specificity (IC₅₀= 53 nM for PKC_α, 195 nM for PKC_βI, 163 nM for PKC_βII, 213 nM for PKC_γ, and 175 nM for PKC_ε). Inhibits carbachol-evoked noradrenaline release (IC₅₀= 600 nM).
A cell-permeable, reversible, selective protein kinase C (PKC) inhibitor that acts at the ATP binding site of PKC (IC₅₀= 158 nM for rat brain PKC). Does not inhibit the tyrosine phosphorylation or the activation of phospholipase C_γ1unlike staurosporine and other serine/threonine kinase inhibitors. IC₅₀values for individual PKC isozymes are as follows: 53 nM for PKC_α, 195 nM for PKC_βI, 163 nM for PKC_βII, 213 nM for PKC_γ, and 175 nM for PKC_ε. Inhibits carbachol-evoked noradrenaline release (IC₅₀= 0.6 ?M).

包装

1 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Primary Target
rat brain PKC
Product competes with ATP.
Target IC₅₀: 158 nM against rat brain PKC; 53 nM for PKCα, 195 nM for PKCβ, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following initial use, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Zhang, C., et al. 1997.J. Immunol.158,4968.
Turner, N.A., et al. 1996.J. Neurochem.66,2381.
Ozawa, K., et al. 1993.J. Biol. Chem.268,1749.
Wilkinson, S.E., et al. 1993.Biochem. J.294,335.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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