半岛bd体育手机客户端 说明
一般描述
A cell-permeable quinazoline compound that acts as a highly potent inhibitor of NF-κB transcriptional activation (IC50= 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC50= 7 nM in murine splenocytes). Shown to exhibit anti-inflammatory effect on carrageenin-induced paw edema in rat. A 10 mM (1 mg/281 ?l) solution of NF-κB Activation Inhibitor (Cat. No. 481407) in DMSO is also available.
A cell-permeable quinazoline compound that acts as a potent inhibitor of NF-κB transcriptional activation (IC50= 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC50= 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 ?M. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats.
包装
1 mg in Plastic Bag(s)
Packaged under inert gas
生化/生理作用
Product does not compete with ATP.
Cell permeable: yes
Primary Target
NF-κB transcriptional activation
Reversible: no
Target IC50: 11 nM against NF-κB transcriptional activation in Jurkat cells
警告
Toxicity: Toxic (F)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Tobe, M., et al. 2003.Bioorg. Med. Chem.11,383.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C22H20N4O |
| 分子量 | 356.42 |
| MDL编号 | MFCD06411436 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | off-white |
| 溶解性 | DMSO: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
Sigma-Aldrich
m.cnreagent.com
