Monoclonal Anti-Protein Tyrosine Phosphatase μ antibody produced in mouse

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一般描述

Among the post-translational modifications, phosphorylation is a vital regulatory mechanism of key proteins involved in specific pathways. Reverse phosphorylation has become recognized as the key process of regulation of gene expression, cellular proliferation, differentiation in Eukaryotes. The protein phosphatases can be divided into two main groups: protein tyrosine phosphatases (PTPs) and protein serine/threonine phosphatases (PPs) which remove phosphate from proteins/peptides containing phosphotyrosine (pTyr) or phosphoserine/phosphothreonine (pSer/pThr), respectively. Several of the PTPs are known to control the function of growth factor receptors, many of which are tyrosine kinases encoded by oncogenes. PTPmu participates in homophilic binding of extracellular surface of adjacent cells. PTPmu is reported to be downregulated in glioblastoma in which it regulates cell migration and growth factor-independent survival
Monoclonal Anti-Protein Tyrosine Phosphatase mu recognizes PTPmu isoforms in all mammalian species.

免疫原

peptide corresponding to amino acid residues 42-60 of PTPμ.

应用

Anti-protein tyrosine phosphatase mu may be used for detection by immunoblotting at a working concentration of 1 to 10 μg/mL. The antibody is suitable for immunoprecipitation.

外形

Solution in phosphate buffered saline with 0.08% sodium azide.

制备说明

Purified from tissue culture supernatant using Protein G.

基本信息

MDL编号	MFCD03097182
NACRES	NA.44

半岛bd体育手机客户端 性质

质量水平	200
生物来源	mouse
偶联物	unconjugated
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	SBK10, monoclonal
形式	buffered aqueous solution
分子量	antigen 200 kDa
species reactivity	bovine, mouse, rat, human
technique(s)	immunoprecipitation (IP): suitable western blot (chemiluminescent): 1-10 μg/mL
同位素/亚型	IgG1
UniProt登记号	P28827
运输	dry ice
储存温度	?20℃
Gene Information	human ... PTPRM(5797) mouse ... Ptprm(19274) rat ... Ptprm(29616)