半岛bd体育手机客户端 说明

应用

Ionomycin is an ionophore produced by the bacteriumStreptomyces conglobatus. It has been shown to induce central demyelination , inhibit adrenal bovine TREK-1 channels , and to regulate cell division of mature human B cells . It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.

生化/生理作用

Ca²⁺ionophore that is more effective than A23187 as a mobile ion carrier for Ca²⁺; non-fluorescent; used to study Ca²⁺transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.
Ionomycin is a Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent. It is used to study Ca2+ transport across biological membranes and induces apoptotic degeneration of embryonic cortical neurons.

基本信息

经验(实验)分子式	C41H70CaO9
分子量	747.07
EC 号	200-664-3
MDL编号	MFCD00083634
PubChem化学物质编号	329815372
NACRES	NA.85

半岛bd体育手机客户端 性质

质量水平	300
生物来源	Streptomyces conglobatus
测定	≥98% (HPLC)
保质期	2 yr
浓度	1 mM in DMSO
颜色	colorless
mp	18.4 ℃
抗生素抗菌谱	Gram-positive bacteria
作用机制	cell membrane | interferes
运输	wet ice
储存温度	?20℃
SMILES string	C[C@@H]1CCC(=O)O[Ca]OC(=CC(=O)[C@@H](C)C[C@@H](C)C1)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]2CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H](C)O
InChI	1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1
InChI key	WKRWUYKLUMMAKG-WYGBAUISSA-L

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1
闪点(F)	188.6 °F - closed cup
闪点(C)	87 ℃ - closed cup
个人防护装备	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)