半岛bd体育手机客户端 说明
一般描述
A cell-permeable, potent, specific, and ATP-competitive inhibitor of GSK-3β (Ki= 25 nM) that exhibits minimal inhibition against a panel of 79 commonly studied protein kinases, including several PKC isozymes. Shown to increase intracellular glycogen synthase activity in HEK293 cells (EC50= 32 nM) and demonstrate metabolic stability in human liver microsomes (HLM; t1/2>100 min).
A cell-permeable azaindolylmaleimide compound that acts as a potent, specific, and ATP-competitive inhibitor of GSK-3β (Ki= 25 nM) and minimally inhibits a panel of 79 commonly studied protein kinases, including several PKC isozymes. Shown to increase intracellular glycogen synthase activity in HEK293 cells with an EC50of 32 nM and demonstrate metabolic stability in human liver microsomes (HLM; t1/2>100 min).
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
Gsk-3β
Reversible: no
Product competes with ATP.
Target Ki: 25 nM against GSK-3β
警告
Toxicity: Carcinogenic / Teratogenic (D)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Justman, Q.A., et al. 2009.Science324,509.
O′Neill, D.J., et al. 2004.Bioorg. Med. Chem.12,3167.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C18H15N5O3 |
| 分子量 | 349.34 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | orange-red |
| 溶解性 | DMSO: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
Sigma-Aldrich
m.cnreagent.com
