CD152/Fc Chimera, Non-cytolytic from mouse

半岛bd体育手机客户端 说明

一般描述

The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain in which mutations to the complement (C1q) and FcγR I binding sites of the Fcγ2a fragment render the Fc fusion protein incapable of direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

生化/生理作用

CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86.

外形

Lyophilized from solution of 0.2 μm filtered, in phosphate buffered saline, pH 7.4, with no preservative added.

制备说明

Purified from serum-free tissue culture supernatant

基本信息

MDL编号	MFCD01092888
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	200
重组	expressed in NS.1 cells
测定	≥98% (SDS-PAGE)
形式	lyophilized
分子量	97 kDa
UniProt登记号	P09793
运输	wet ice
储存温度	?20℃
Gene Information	mouse ... Ctla4(12477)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)