半岛bd体育手机客户端 说明
一般描述
A tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC50= 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC50= 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells.
A tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC50= 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC50= 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells.
Note: aldehyde-based inhibitors are less cell-permeable than FMK-based inhibitors, so higher concentrations may be required for cell-based inhibition studies (e.g. 100 ?M).
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Target IC50: 3.2 nM and 22.6 nM, against caspases-3 and -7, respectively
Product does not compete with ATP.
Reversible: yes
Primary Target
caspase-3, caspase-7
Cell permeable: no
警告
Toxicity: Standard Handling (A)
序列
Ac-Asp-Asn-Leu-Asp-CHO
分析说明
Single main spot with additional trace spot by TLC
其他说明
Yoshimori, A., et al. 2004.BMC Pharmacol.4,7.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C20H31N5O10 |
| 分子量 | 501.49 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | white |
| 溶解性 | water: 1 mg/mL DMSO: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
