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β-Secretase inhibitor

品牌
Sigma-Aldrich
货号
S4562
规格纯度
≥97% (HPLC), powder
价格
5655.53 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
β-Secretase inhibitor
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

Amino Acid Sequence

Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe

一般描述

β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1), an aspartic protease belongs to the protease family of enzymes comprises of six luminal cysteine residues. These residues help in the formation of three intermolecular disulfide bonds and N-linked glycosylation sites.

应用

β-Secretase inhibitor has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay.(2)
β-Secretase inhibitor may be used to inhibit BACE1 in studies related to AD.

生化/生理作用

β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is a β-secretase that initiates the production of amyloid protein in Alzheimer′s dieases (AD) patients. β-Secretase inhibitors decrease the generation of β amyloid and formation of amyloid plaques typical of AD.

基本信息

经验(实验)分子式 C73H118N16O27
分子量 1651.81
MDL编号 MFCD02683580
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 200
生物来源 synthetic (organic)
测定 ≥97% (HPLC)
形式 powder
分子量 ~_1.65 kDa
颜色 white
mp 200 ℃
溶解性 DMSO: soluble
运输 dry ice
储存温度 ?20℃

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, type N95 (US)

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