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Arzanol

品牌
Sigma-Aldrich
CAS
32274-52-5
货号
SBR00002
规格纯度
fromHelichrysum italicum, ≥98%
价格
1933.63 *本价格含增值税费
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半岛bd体育手机客户端 名称:
32274-52-5
Arzanol
3-[[3-Acetyl-2,4,6-trihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]methyl]-6-ethyl-4-hydroxy-5-methyl-2 H-pyran-2-one
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一般描述

Arzanol is a polyphenol compound extracted from the plantHelichrysum italicumwhich grows in the Mediterranean area.

生化/生理作用

Arzanol is a polyphenol compound extracted from the plantHelichrysum italicumwhich grows in the Mediterranean area. Arzanol is known for its anti-inflammatory and antimicrobial activities.The anti-inflammatory activity was verified in anin-vivorat model and was found to suppress the inflammatory response of the carrageenan-induced pleurisy.Moreover it was found to have an anti-HIV-1 activity. Arzanol inhibits COX-2-derived prostaglandin synthase-1 (mPGES-1) Inhibitorin-vitro, in human stimulated monocytes.
Arzanol inhibits the activation of inflammatory transcription factor NF κ B, HIV replication in T cells, releases of IL-1β, IL-6, IL-8, and TNF-α,and biosynthesis of PGE2 by potentially inhibiting the mPGES-1 enzyme.
Arzanol is known for its anti-inflammatory and antimicrobial activities. The anti-inflammatory activity was verified in anin-vivorat model and was found to suppress the inflammatory response of the carrageenan-induced pleurisy. Moreover it was found to have an anti-HIV-1 activity. Arzanol inhibits COX-2-derived prostaglandin synthase-1 (mPGES-1) Inhibitorin-vitro, in human stimulated monocytes.
Arzanol inhibits the activation of inflammatory transcription factor nuclear factor- K B (NF- K B), human immunodeficiency virus (HIV) replication in T cells, releases of interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α and biosynthesis of prostaglandin E2 (PGE2) by potentially inhibiting the mPGES-1 enzyme. It also possesses antioxidant and cytotoxic activity.

重悬

Soluble in dimethyl sulfoxide (DMSO) at 1 mg/mL; poorly soluble in water

基本信息

经验(实验)分子式 C22H26O7
分子量 402.44
MDL编号 MFCD28168041
PubChem化学物质编号 329824643
NACRES NA.25

半岛bd体育手机客户端 性质

质量水平 200
生物来源 Helichrysum italicum
测定 ≥98%
形式 powder
储存温度 ?20℃
SMILES string OC1=C(CC2=C(O)C(C)=C(CC)OC2=O)C(O)=C(C(C)=O)C(O)=C1CC=C(C)C
InChI 1S/C22H26O7/c1-6-16-11(4)18(24)15(22(28)29-16)9-14-19(25)13(8-7-10(2)3)20(26)17(12(5)23)21(14)27/h7,24-27H,6,8-9H2,1-5H3
InChI key ZOIAPLVBZQQHCG-UHFFFAOYSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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