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Anti-Serine/Threonine Protein Phosphatase 2 A/Bα antibody produced in rabbit

品牌
Sigma-Aldrich
货号
P8234
规格纯度
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
价格
4330.86 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-Serine/Threonine Protein Phosphatase 2 A/Bα antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Among the post-translational modifications, phosphorylation is a vital regulatory mechanism of key proteins involved in specific pathways. Reverse phosphorylation has become recognized as the key process of regulation of gene expression, cellular proliferation, differentiation in Eukaryotes. Protein phosphatases, like kinases, are a class of enzymes that regulate protein phosphorylation. The serine/threonine phosphatases have been classified into four groups which include PP1, PP2A, PP2B (also termed calcineurin) and PP2C on the basis of differences in their biochemical properties. Protein phosphatase 2A (PP2A) holozyme consists of a catalytic subunit (C), a structural subunit (A) and a regulatory subunit (B). The subunit B dictates the substrate specificity and is coded by at least 13 genes resulting in 3 distinct classes of subunits - α, β and γ. The B α subunit is targeted to the microtubules, renders substrate specificty and dephosphorylates cyclin-dependent kinase sites. The PP2A holoenzyme has been implicated in various functions such as cell cycle progression, oncogenic transformation and is subjected to tight regulation at the translational level, by post translational modifications and by protein-protein interations.
Anti-Serine/Threonine Protein Phosphatase 2A/Bα recognizes protein phosphatase 2A/Bα?isoforms of 55 kDa.

免疫原

synthetic peptide (FSQVKGAVDDDVAE) corresponding to the N-terminus (amino acids 14-27) of the protein phosphatase 2A/Bα subunit.

应用

Anti-Serine/Threonine Protein Phosphatase 2A/B α may be used for detection at working concentration of 5-10 μg/mL in total rat brain homogenate. The antibody is also suitable for immunocytochemistry at a working concentration of 5-10 μg/mL.

外形

Provided as a 0.2 μm filtered solution in phosphate buffered saline containing 0.08% sodium azide.

基本信息

MDL编号 MFCD03455946
NACRES NA.44

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 55 kDa
species reactivity human, bovine, rat, mouse
浓度 ~1 mg/mL
technique(s) immunocytochemistry: 5-10 μg/mL
western blot: 5-10 μg/mL using total rat brain homogenate
UniProt登记号 P63151
运输 dry ice
储存温度 ?20℃
Gene Information human ... PPP2R2A(5520)

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