Anti-phospho-Retinoblastoma (pSer⁷⁸⁰) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

RB1 (RB transcriptional corepressor 1) codes for nuclear phosphoprotein pRB (retinoblastoma protein). It is located on human chromosome 13q14. It is a tumor-suppressor gene.

特异性

Recognizes Rb phosphorylated at Ser⁷⁸⁰and does not react with non-phosphorylated Rb. Does not react with Rb phosphorylated at other sites.

免疫原

synthetic peptide corresponding to residues around pSer⁷⁸⁰of the human retinoblastoma tumor suppressor protein (Rb).

生化/生理作用

RB1 (RB transcriptional corepressor 1) plays an important role throughout G1/S phase transition. Absence of RB induces prostate cancer metastasis. It plays an important role in modulating the cell cycle. It also regulates cell stemness and differentiation.

外形

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin, and 50% glycerol.

制备说明

Purified using protein A and affinity chromatography.

基本信息

MDL编号	MFCD02097166
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous glycerol solution
species reactivity	human, mouse, rat
technique(s)	western blot (chemiluminescent): 1:1,000 using human fibroblasts synchronized by serum deprivation
UniProt登记号	P06400
运输	wet ice
储存温度	?20℃
Gene Information	human ... RB1(5925) mouse ... Rb1(19645) rat ... Rb1(24708)